[New aspects of sepsis pathophysiology in critically ill].
نویسندگان
چکیده
Još od doba Hipokrata koji je 400. godine pne prvi opisao sepsu, imunopatofiziologija ovog kompleksnog oboljenja ostaje kontroverzna tema koja je predmet mnogih istraživanja. I autori ovog opšteg pregleda posvetili su se u poslednjoj dekadi ovoj intrigantnoj oblasti i to sa različtitih aspekata. Naime, proučavali smo disfunkciju različitih organa u sepsi (miokarda i pluća), kao i sindrom multiple organske disfunkcije (MODS), zatim imunsku kaskadu sepse i ulogu proi antiinflamatornih citokina, odnos infekcije i inflamacije, acidobazni status bolesnika sa sepsom i genski polimorfizam kod različitih medijatora i receptora od značaja za težinu i ishod sepse . Svojim istraživanjima u protekllih 10 godina obuhvatili smo veoma veliki broj bolesnika sa traumom i ratnom povredom koje su se veoma često komplikovale sekundarnom sepsom, kao i sepsom druge etiologije a, takođe, ispitivali smo i skorove sepse kod različitih bolesnika.
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ورودعنوان ژورنال:
- Vojnosanitetski pregled
دوره 69 1 شماره
صفحات -
تاریخ انتشار 2012